Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 213 |
| PDBID: | 2AEQ |
| Chains: | HL_A |
| Organism: | Influenza A virus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1016/j.jmb.2005.11.061 |
| Antibody | |
| Antibody: | NA Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus neuraminidase |
| Antigen mutation: | No |
| Durg Target: | P06818 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >2AEQ_H|Chain C[auth H]|FAB heavy chain|Mus musculus (10090) EVKLVESGGGLVQPGGSLSLSCATSGFTFIDYYMSWFRQPPGKALEWLGLIRNKGNGYTMEYSASLKGRFTISRDNSQSIVYLHMNTLTAEDSATYYCARVDYGTNYDYWGQGTTLTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKI |
Light Chain: L
Mutation: NULL
| >2AEQ_L|Chain B[auth L]|FAB light chain|Mus musculus (10090) DILMTQSQKFLSTSVGDRVSVTCKASQNVGTNVAWYQQKPGQSPKPLMYSASYRYSGVPDRFTGSGSGTDFTLTISNVQSEDLAEYFCQQFNRYPLTFGSGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >2AEQ_A|Chain A|neuraminidase|Influenza A virus (11320) KEICPKLAEYRNWSKPQCKITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPDKCYQFALGQGTTLNNRHSNDTVHDRTPYRTLLMNELGVPFHLGTKQVCIAWSSSSCHDGKAWLHVCVTGHDENATASFIYDGRLVDSIGSWSKKILRTQESECVCINGTCTVVMTDGSASGRADTKILFIEEGKIVHISPLSGSAQHVEECSCYPRYPGVRCVCRDNWKGSNRPIVDINVKDYSIVSSYVCSGLVGDTPRKNDSSSSSHCLNPNNEEGGHGVKGWAFDDGNDVWMGRTISEKFRSGYETFKVIEGWSKPNSKLQINRQVIVDRGNRSGYSGIFSVEGKSCINRCFYVELIRGRKQETEVWWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: THR31 ASN32 TYR49 SER50 TYR53 SER56 PHE91 ASN92 TYR94 H: ILE30 ASP31 TYR33 ARG52 ASN53 LYS54 GLY55 ASN56 THR59 GLU61 TYR103 GLY104 THR105 ASN106 A: ASP147 VAL149 HIS150 ARG152 THR153 PRO154 TYR155 HIS197 ASP198 GLU199 ASN200 TRP218 SER219 LYS220 LYS221 ILE222 ARG224 GLY244 SER245 ALA246 SER247 GLY248 ARG249 ALA250 ASP251 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
