Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2116 |
| PDBID: | 6CMI |
| Chains: | DC_B |
| Organism: | Hendra virus horse/Australia/Hendra/1994, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.72 |
| Reference: | 10.1371/journal.ppat.1003684 |
| Antibody | |
| Antibody: | m102.3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hendra Virus Attachment Glycoprotein G |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >6CMI_D|Chain C[auth D]|IgG Heavy chain|Homo sapiens (9606) EVQLVQSGAEVKKRGSSVKVSCKSSGGTFSNYAINWVRQAPGQGLEWMGGIIPILGIANYAQKFQGRVTITTDESTSTAYMELSSLRSEDTAVYYCARGWGREQLAPHPSQYYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: C
Mutation: NULL
| >6CMI_C|Chain B[auth C]|m102.3 light chain|Homo sapiens (9606) EIVMTQSPGTPSLSPGERATLSCRASQSIRSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGRSPSFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKLYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >6CMI_B|Chain A[auth B]|Glycoprotein G|Hendra virus (928303) QGVSDLVGLPNQICLQKTTSTILKPRLISYTLPINTREGVCITDPLLAVDNGFFAYSHLEKIGSCTRGIAKQRIIGVGEVLDRGDKVPSMFMTNVWTPPNPSTIHHCSSTYHEDFYYTLCAVSHVGDPILNSTSWTESLSLIRLAVRPKSDSGDYNQKYIAITKVERGKYDKVMPYGPSGIKQGDTLYFPAVGFLPRTEFQYNDSNCPIIHCKYSKAENCRLSMGVNSKSHYILRSGLLKYNLSLGGDIILQFIEIADNRLTIGSPSKIYNSLGQPVFYQASYSWDTMIKLGDVDTVDPLRVQWRNNSVISRPGQSQCPRFNVCPEVCWEGTYNDAFLIDRLNWVSAGVYLNSNQTAENPVFAVFKDNEILYQVPLAEDDTNAQKTITDCFLLENVIWCISLVEIYDTGDSVIRPKLFAVKIPAQCSE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: ARG30 THR32 TYR33 D: SER30 ASN31 ILE54 LEU55 GLY56 ILE57 ARG102 GLU103 GLN104 LEU105 ALA106 PRO107 HIS108 PRO109 SER110 GLN111 TYR112 TYR113 TYR114 TYR115 B: GLU213 GLY214 THR218 GLY238 SER239 CYS240 THR241 ARG242 LEU305 TYR458 PRO488 GLY489 GLN490 TRP504 GLU505 GLY506 THR507 ASN527 SER528 GLN530 THR531 ALA532 GLU533 ASN534 ASP554 ASP555 ASN557 ALA558 GLN559 GLU579 TYR581 THR583 SER586 ILE588 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
