Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2101 |
| PDBID: | 6CE0 |
| Chains: | HL_G |
| Organism: | Human immunodeficiency virus 1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 4.60 |
| Reference: | 10.1126/sciadv.aau6769 |
| Antibody | |
| Antibody: | PGT124 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 clade B tier-3 isolate H078.14 UFO-BG gp160 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6CE0_H|Chain E[auth H]|PGT124 Heavy chain|Homo sapiens (9606) QVQLQESGPGLVRPSETLSVTCIVSGGSISNYYWTWIRQSPGKGLEWIGYISDRETTTYNPSLNSRAVISRDTSKNQLSLQLRSVTTADTAIYFCATARRGQRIYGVVSFGEFFYYYYMDVWGKGTAVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCD |
Light Chain: L
Mutation: NULL
| >6CE0_L|Chain F[auth L]|PGT124 Light chain|Homo sapiens (9606) SYVSPLSVALGETARISCGRQALGSRAVQWYQHKPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTTATLTISGVEVGDEADYYCHMWDSRSGFSWSFGGATRLTVLSQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: G
Mutation: NULL
| >6CE0_G|Chain B[auth G]|Envelope glycoprotein gp160|Human immunodeficiency virus 1 (11676) AEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVLLENVTEEFNMWKNSMVEQMHEDIISLWDQSLKPCVKLTPFCVTLNCTNYNGTNGNTTVTNNSTGDGDIKQCSFNITTEIEDKDGSKRRNESALFSKLDLEPINNSNTSYRLIKCNTSVIKQACPKVSFEPIPIHYCAPAGFAILKCNDKRFNGTGPCKNVSTVQCTHGIKPVVSTQLLLNGSLAEEEVVIRSENLTNNAKNIIIQLNESVVITCERPNNNTRKRVTLGPGKVLYTTGEIIGNIRKAHCNISKTNWTRTLERIVIKLREQFKNKTIVFNQSSGGDLEIVMHVFNCGGEFFYCNTTQLFNSTYNSTWNYNSTRNTTDSIITLPCRIKQIINRWQEVGKAMYAPPIAGQIRCQSNITGLILTRDGGGNGTNGTEVFRPAGGDMKDNWRSELYKYKVVRIEPLGIAPTKCKRRVVGGGGGSGGGGS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: LEU28 GLY29 SER30 ASN66 SER93 ARG94 G: TYR134 GLY324 ASN325 ILE326 ARG327 LYS328 ALA329 HIS330 THR415 PRO417 GLN442 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
