Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2089 |
| PDBID: | 6BPE |
| Chains: | HI_G |
| Organism: | Plasmodium vivax Sal-1, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.34 |
| Reference: | 10.1038/s41586-018-0249-1 |
| Antibody | |
| Antibody: | 6H1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6BPE_H|Chain B, E, H|Monoclonal antibody 6H1 Fab heavy chain|Mus musculus (10090) MYFRLSSVFLVLILKGVQCEVKLVESEGGLVQPGSSMNLSCTASGFTFSDYYMAWVRQVPDKGLEWVASVSYDGSITYYLDSLKSRFIISRDNVKNILNLQMSSLKSEDTATYYCTRVTVVDSFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNS |
Light Chain: I
Mutation: NULL
| >6BPE_I|Chain C, F, I|Monoclonal antibody 6H1 Fab light chain|Mus musculus (10090) MGIKMESQTQVFVYMLLWLSGVDGDIVMTQSQKFMSTSIGVRVSVTCKASQNVGTNVAWYQQKPGQSPKALIYSASYRNSGVPDRFTGSGSGTEFTLTISNVQSEDLAEYFCQQYDSYPYPFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: G
Mutation: NULL
| >6BPE_G|Chain A, D, G, J|Reticulocyte binding protein 2, putative|Plasmodium vivax (strain Salvador I) (126793) GAMGSTNTTDNIDYFDISDESNYYLISQLRPHFSNIYFFDEFKRYASYHTEIKRYEDIHKTKVNSLLNEASRAIGICNRAKNTVKGLINILENPQKFKTQRESYDVKLRQYEEKKEAFRGCLLNKNRKNLDQIKKINNEIRDLLEKLKCSQDCQTNVYFDMIKIYLVDFKKMPYENYDTFIKQYKNSYLSGVDMIRKIEKQIDNPVTINAIKFTQKEMGYIIDRFEYHLQKVKHSIDQVTALSDGVKPKQVTKNRLKEYYFNIGNYYSIFKFGKDSLNMLNKALIHKEKIVHNLLGELFGHLEERIS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR47 SER49 ASP50 TYR51 TYR52 SER71 TYR72 ASP73 SER75 ILE76 TYR78 VAL118 THR119 VAL120 VAL121 ASP122 I: VAL53 GLY54 THR55 ASN56 TYR73 SER74 TYR77 SER91 TYR115 ASP116 G: GLU214 ARG217 ASP220 ILE221 THR224 LYS225 LYS298 GLU302 ASP305 LEU306 GLU308 LYS309 LEU310 LYS311 SER313 LYS416 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
