Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2081 |
| PDBID: | 6BKD |
| Chains: | HL_E |
| Organism: | Recombinant Hepatitis C virus HK6a/JFH-1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.25 |
| Reference: | 10.1126/sciadv.aav1882 |
| Antibody | |
| Antibody: | AR3D Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C Virus Glycoprotein |
| Antigen mutation: | Yes |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6BKD_H|Chain B[auth H]|Fab AR3D heavy chain|Homo sapiens (9606) LLEQSGAEVKKPGSSVKVSCKASGDTFRSYVITWARQAPGQGLEWMGAIIPFFGTTNLAQKFQGRVTITADESTKTVYMDLSSLRSDDTAVYYCAKAGDLSVGGVLAGGVPHLRHFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCGS |
Light Chain: L
Mutation: NULL
| >6BKD_L|Chain C[auth L]|Fab AR3D light chain|Homo sapiens (9606) ELTQSPGTLSLSPGERATLSCRAGQTVASNSLAWYQHKPGQAPRLLIYGASIRASGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGLSSTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: N37D
| >6BKD_E|Chain A[auth E]|Polyprotein|Recombinant Hepatitis C virus HK6a/JFH-1 (595609) QLINTNGSWHINRTALNCNDSLQTGFITSLFYAKNVDSSGCPERMAACGSSGCWHYAPRPCDVVSARTVCGPVYCFTPSPVVVGTTDKLGIPTYNWGENETDVFMLESLRPPTGGWFGCTWMNSTGFTKTCGAPPGGPTDGGSGPWITPRCLVDYPYRLWHYPCTVNFTLHKVRMFVGGIEHRFDAACN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR28 ARG30 SER31 PHE53 PHE54 THR56 LEU98 SER99 E: ILE422 THR425 LEU427 ASN428 CYS429 ASN430 ASP431 SER432 GLN434 GLY436 ILE438 THR439 LEU441 PHE442 TYR443 TRP529 GLU531 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
