Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2080 |
| PDBID: | 6BKC |
| Chains: | HL_E |
| Organism: | Homo sapiens, Recombinant Hepatitis C virus HK6a/JFH-1 |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1126/sciadv.aav1882 |
| Antibody | |
| Antibody: | AR3B Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C Virus Glycoprotein |
| Antigen mutation: | Yes |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6BKC_H|Chain A[auth H]|Fab AR3B heavy chain|Homo sapiens (9606) LLEQSGPEVKKPGSSVKVSCKDSGDTFNEPVTWVRQAPGQGLEWIGGIIPAFGVTKYAQKFQGRVIISADASTATAYLELSSLRSEDTAVYYCAKVGLRGIVMVGGLAMNWLDPWGQGTQVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCGS |
Light Chain: L
Mutation: NULL
| >6BKC_L|Chain B[auth L]|Fab AR3B light chain|Homo sapiens (9606) EIELTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPQTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: N37D
| >6BKC_E|Chain C[auth E]|Polyprotein|Recombinant Hepatitis C virus HK6a/JFH-1 (595609) QLINTNGSWHINRTALNCNDSLQTGFITSLFYAKNVDSSGCPERMAACGSSGCWHYAPRPCDVVSARTVCGPVYCFTPSPVVVGTTDKLGIPTYNWGENETDVFMLESLRPPTGGWFGCTWMNSTGFTKTCGAPPGGPTDGGSGPWITPRCLVDYPYRLWHYPCTVNFTLHKVRMFVGGIEHRFDAACN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASN30 GLU32 PRO33 ALA53 PHE54 GLY55 VAL56 LYS58 LEU97 ARG98 GLY99 L: TYR32 TYR49 E: ILE422 THR425 LEU427 ASN428 CYS429 ASN430 ASP431 SER432 GLN434 THR435 GLY436 ILE438 THR439 LEU441 PHE442 ARG500 PRO505 ASN528 TRP529 GLU531 TYR613 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
