Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2079 |
| PDBID: | 6BKB |
| Chains: | HL_E |
| Organism: | Homo sapiens, Recombinant Hepatitis C virus HK6a/JFH-1 |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1126/sciadv.aav1882 |
| Antibody | |
| Antibody: | AR3A Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C Virus Glycoprotein |
| Antigen mutation: | Yes |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6BKB_H|Chain A[auth H]|Fab AR3A heavy chain|Homo sapiens (9606) VQLLEQSGAEVKTPGSSVRVSCRPPGGNFNSYSINWVRQAPGHGLEWVGTFIPMFGTSKYAQKFQGRVTITADGSSGTAYMDLNSLRSDDTAFYYCVRPETPRYCSGGFCYGEFDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCGS |
Light Chain: L
Mutation: NULL
| >6BKB_L|Chain C[auth L]|Fab AR3A light chain|Homo sapiens (9606) ELTLTQSPGTLSLSPGKRATLSCRASQSVSGSYLAWYQQKPGQAPRLLIYGASNRATGIPHRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPTFGQGTRVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: N37D
| >6BKB_E|Chain B[auth E]|Polyprotein|Recombinant Hepatitis C virus HK6a/JFH-1 (595609) QLINTNGSWHINRTALNCNDSLQTGFITSLFYAKNVDSSGCPERMAACGSSGCWHYAPRPCDVVSARTVCGPVYCFTPSPVVVGTTDKLGIPTYNWGENETDVFMLESLRPPTGGWFGCTWMNSTGFTKTCGAPPGGPTDGGSGPWITPRCLVDYPYRLWHYPCTVNFTLHKVRMFVGGIEHRFDAACN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASN30 SER31 TYR32 MET53 PHE54 THR56 GLU96 THR97 PRO98 ARG99 L: GLY30 SER31 TYR32 TYR49 GLY50 ASN53 E: ILE422 LEU427 ASN428 CYS429 ASN430 ASP431 SER432 GLN434 GLY436 ILE438 THR439 LEU441 PHE442 TYR443 TRP529 GLU531 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
