Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 207 |
| PDBID: | 1ZVY |
| Chains: | A_B |
| Organism: | Camelus dromedarius, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 1.63 |
| Reference: | 10.1073/pnas.0505379103 |
| Antibody | |
| Antibody: | D3-L11 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hen Egg White Lysozyme |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >1ZVY_A|Chain A|Immunoglobulin heavy chain antibody variable domain|Camelus dromedarius (9838) DVQLVESGGGSVQAGGSLRLSCAASGSTDSIEYMTWFRQAPGKAREGVAALYTHTGNTYYTDSVKGRFTISQDKAKNMAYLRMDSVKSEDTAIYTCGATRKYVPVRFALDQSSYDYWGQGTQVTVSSRGRHHHHHH |
Antigen
Chain: B
Mutation: NULL
| >1ZVY_B|Chain B|Lysozyme C|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASP29 SER30 GLU32 TYR52 HIS54 THR55 ASN57 TYR59 ARG100 LYS101 TYR102 VAL103 PRO104 VAL105 ARG106 PHE107 SER112 SER113 ASP115 B: ASN46 ASP48 ASN59 ARG61 TRP62 TRP63 ARG73 LEU75 LYS97 ASP101 GLY102 ASN103 ASN106 ALA107 VAL109 ARG112 ASN113 LYS116 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
