Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2066 |
| PDBID: | 6BDZ |
| Chains: | HL_A |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.10 |
| Reference: | 10.1016/j.cell.2017.11.014 |
| Antibody | |
| Antibody: | 11G2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Disintegrin and metalloproteinase domain-containing protein 10 |
| Antigen mutation: | No |
| Durg Target: | O14672 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6BDZ_H|Chain B[auth H]|11G2 Fab Heavy Chain|Mus musculus (10090) QVQLKESGPGLVAPSQSLSITCTVSGFSLTGYGVNWVRQPPGKGLEWLGVIWGDGTTDYNSTLKSRLSISKDNSKSQVFLKMNSLQTVDTARYYCARDGDYGRLDYWGQGTTLTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCIC |
Light Chain: L
Mutation: NULL
| >6BDZ_L|Chain A[auth L]|11G2 Fab Light Chain|Mus musculus (10090) QIVLTQSPAIMSASLGERVTMTCTVSSSVSSGYLHWYQQKSGSSPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISSMGAEDAATYYCHQYRRSPLTFGAGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >6BDZ_A|Chain C[auth A]|Disintegrin and metalloproteinase domain-containing protein 10|Homo sapiens (9606) NTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRQISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRQISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPQFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLGGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR55 TYR114 ARG115 ARG116 SER117 H: THR49 GLY50 TYR51 GLY52 TRP71 GLY72 ASP73 THR75 THR76 ASP77 ASP117 GLY118 ASP119 TYR120 GLY121 A: GLU470 SER476 CYS479 ASP481 GLU482 CYS484 PHE485 ASP486 ASN488 GLN489 PRO490 GLU491 GLY492 ARG493 LYS496 LEU497 LYS498 PRO499 GLY500 LYS501 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
