Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2064 |
| PDBID: | 6BAN |
| Chains: | HG_P |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.95 |
| Reference: | 10.1073/pnas.1719905115 |
| Antibody | |
| Antibody: | R11 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Inactive tyrosine-protein kinase transmembrane receptor ROR1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6BAN_H|Chain B, D, F, H|Variable domain R11 Heavy chain|Homo sapiens (9606) SQSVKESEGDLVTPAGNLTLTCTASGSDINDYPISWVRQAPGKGLEWIGFINSGGSTWYASWVKGRFTISRTSTTVDLKMTSLTTDDTATYFCARGYSTYYGDFNIWGPGTLVTISS |
Light Chain: G
Mutation: NULL
| >6BAN_G|Chain A, C, E, G|Variable domain of R11 Light Chain|Homo sapiens (9606) GSHMELVMTQTPSSTSGAVGGTVTINCQASQSIDSNLAWFQQKPGQPPTLLIYRASNLASGVPSRFSGSRSGTEYTLTISGVQREDAATYYCLGGVGNVSYRTSFGGGTEVVVK |
Antigen
Chain: P
Mutation: NULL
| >6BAN_P|Chain I[auth M], J[auth N], K[auth O], L[auth P]|Inactive tyrosine-protein kinase transmembrane receptor ROR1|Homo sapiens (9606) MHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPAC |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: TYR50 ARG51 SER57 ASN95 H: GLY25 SER26 ASP27 ILE28 ASP30 TYR31 PRO32 PHE49 ASN51 SER52 TRP57 ARG94 GLY95 TYR96 TYR100 GLY101 ASP102 ASN104 P: LYS329 SER330 GLY331 ARG332 GLN368 LYS369 GLU370 ASP378 GLU379 ASN380 PHE381 LYS382 SER383 ASP384 LEU385 ASP387 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
