Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 206 |
| PDBID: | 1ZVH |
| Chains: | A_L |
| Organism: | Gallus gallus, Camelus dromedarius |
| Method: | XRD |
| Resolution (Å): | 1.50 |
| Reference: | 10.1073/pnas.0505379103 |
| Antibody | |
| Antibody: | D2-L24 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hen Egg White Lysozyme |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >1ZVH_A|Chain B[auth A]|Immunoglobulin heavy chain antibody variable domain|Camelus dromedarius (9838) DVQLVESGGGSVQAGGSLRLSCAASGYIASINYLGWFRQAPGKEREGVAAVSPAGGTPYYADSVKGRFTVSLDNAENTVYLQMNSLKPEDTALYYCAAARQGWYIPLNSYGYNYWGQGTQVTVSSRGRHHHHHH |
Antigen
Chain: L
Mutation: NULL
| >1ZVH_L|Chain A[auth L]|Lysozyme C|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASP1 TYR27 SER30 ARG100 GLN101 GLY102 TRP103 TYR104 ILE105 TYR110 GLY111 ASN113 L: LYS1 GLN41 THR43 TYR53 ASN65 ASP66 GLY67 ARG68 ASN74 ASN77 ILE78 PRO79 SER81 ALA82 LEU84 SER85 SER86 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
