Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2050 |
| PDBID: | 6B0S |
| Chains: | HL_C |
| Organism: | Homo sapiens, Plasmodium falciparum |
| Method: | XRD |
| Resolution (Å): | 1.95 |
| Reference: | 10.1084/jem.20170869 |
| Antibody | |
| Antibody: | 1710 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Circumsporozoite protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6B0S_H|Chain A[auth H]|1710 antibody, heavy chain|Homo sapiens (9606) EVQLQESGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSITSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDPGIAAADNHWFDPWGQGTLVTVSSASTKGPSVFPLAPSSSSKSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: L
Mutation: NULL
| >6B0S_L|Chain B[auth L]|1710 antibody, light chain|Homo sapiens (9606) SAYELTQPPSVSVSPGQTASITCSGDKLGDKYACWYQQKPGQSPVVVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: C
Mutation: NULL
| >6B0S_C|Chain C|Circumsporozoite protein|Plasmodium falciparum (5833) ETGYVEFEPSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKMEKCPHHHHHHALE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER31 SER33 SER52 SER53 SER55 TYR56 ILE98 ALA99 L: GLY29 ASP30 LYS31 TYR32 GLN50 ASP51 LYS53 ASN66 TRP91 C: LYS314 LYS317 GLU318 LEU320 ASN321 GLN324 LEU327 LYS353 PRO354 LYS355 ASP356 GLU357 LEU358 ASP359 TYR360 ALA361 ILE364 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
