Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 205 |
| PDBID: | 1ZV5 |
| Chains: | A_L |
| Organism: | Gallus gallus, Camelus dromedarius |
| Method: | XRD |
| Resolution (Å): | 2.00 |
| Reference: | 10.1073/pnas.0505379103 |
| Antibody | |
| Antibody: | D2-L29 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hen Egg White Lysozyme |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >1ZV5_A|Chain B[auth A]|immunoglobulin heavy chain antibody variable domain|Camelus dromedarius (9838) DVQLVESGGGSVQAGESLRLSCAASGVTYKNYCIGWFRQAPGKDREGVVFINSDGGITYYADSVKGRFTISQDNAKNTVYLQMNSLKPEDTASYYCAAGYRNYGQCATRYWGQGTQVTVSSRGRHHHHHH |
Antigen
Chain: L
Mutation: NULL
| >1ZV5_L|Chain A[auth L]|Lysozyme C|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TYR29 LYS30 ASN31 PHE37 ASP44 ARG45 GLY47 PHE50 TYR60 TYR100 ARG101 ASN102 TYR103 GLN105 CYS106 ALA107 THR108 ARG109 TYR110 TRP111 L: PHE34 GLU35 THR43 ASN44 ARG45 ASN46 THR47 ASP48 ASP52 GLN57 ARG68 VAL109 ALA110 ARG112 ASN113 ARG114 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
