Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2046 |
| PDBID: | 6B0H |
| Chains: | CD_I |
| Organism: | Plasmodium falciparum, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.70 |
| Reference: | 10.1038/s41467-017-01924-3 |
| Antibody | |
| Antibody: | 1262 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Pfs25 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6B0H_C|Chain E[auth A], F[auth C]|1262 antibody, light chain|Homo sapiens (9606) DIQLTQSPSFLSASVGDRVTITCWASQGINSYLAWYQQKPGKTPKLLIYAASTLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQLNSYPCSFGQGTTLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Light Chain: D
Mutation: NULL
| >6B0H_D|Chain C[auth B], D|1262 antibody, heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSGTLSLTCAVSGGSISSSHWWSWVRQPPGKGLEWVGEISLSGSTHYGPSLKSRVSISLDKSMNHFSLRLSSVTAADTAVYYCARESRFYGAYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Antigen
Chain: I
Mutation: NULL
| >6B0H_I|Chain A[auth I], B[auth J]|Pfs25|Plasmodium falciparum (5833) TGAKVTVDTVCKRGFLIQMSGHLECKCENDLVLVNEETCEEKVLKCDEKTVNKPCGDFSKCIKIDGNPVSYACKCNLGYDMVNNVCIPNECKQVTCGNGKCILDTSNPVKTGVCSCNIGKVPNVQDQNKCSKDGETKCSLKCLKEQETCKAVDGIYKCDCKDGFIIDQESSICTGTKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: SER30 SER31 SER32 HIS33 TRP34 LEU53 SER54 ARG94 ARG97 PHE98 TYR99 C: ASN30 TYR32 TYR49 SER52 THR53 LEU54 GLN55 SER56 LEU91 ASN92 SER93 TYR94 I: LEU75 ASP78 ASN87 GLU88 LYS90 GLN91 VAL92 THR93 ASP102 SER104 ASN105 PRO106 VAL107 LYS108 THR109 GLY110 VAL111 CYS112 PRO120 VAL122 GLN123 GLN125 ASN126 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
