Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2045 |
| PDBID: | 6B0G |
| Chains: | DC_E |
| Organism: | Homo sapiens, Plasmodium falciparum NF54 |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1038/s41467-017-01924-3 |
| Antibody | |
| Antibody: | 1245 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Pfs25 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >6B0G_D|Chain B[auth D]|1245 Antibody, Heavy Chain|Homo sapiens (9606) QVQLVQSGGEVKKPGASVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGWISAYNGNRKYAQKVQGRVSMTIDTHTSTANMELRSLRSDDTAVYYCAKDRGDGDYRYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: C
Mutation: NULL
| >6B0G_C|Chain A[auth C]|1245 Antibody, Light Chain|Homo sapiens (9606) DVVMTQSPLSLPVTLGQPASISCRSSQSLVYSDGNTYLSWFQQRPGQSPRRLIYKVSNRDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQDTHWPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >6B0G_E|Chain C[auth E]|25 kDa ookinete surface antigen|Plasmodium falciparum (5843) TGAKVTVDTVCKRGFLIQMSGHLECKCENDLVLVNEETCEEKVLKCDEKTVNKPCGDFSKCIKIDGNPVSYACKCNLGYDMVNNVCIPNECKQVTCGNGKCILDTSNPVKTGVCSCNIGKVPNVQDQNKCSKDGETKCSLKCLKEQETCKAVDGIYKCDCKDGFIIDQESSICTGTKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: SER27 ASP28 GLY29 ASN30 THR31 TYR49 ASN53 SER56 D: SER31 TYR32 TYR53 ARG96 GLY97 ASP98 E: PHE13 ILE15 MET17 GLU22 LYS24 CYS25 GLU26 ASN27 ASP28 LYS40 ASN81 ASN82 VAL83 THR93 GLY95 ASN96 GLY97 LYS98 ASN115 ILE116 SER129 LYS148 ALA149 VAL150 ASP151 GLY152 ILE153 LYS155 ASP157 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
