Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2043 |
| PDBID: | 6B0A |
| Chains: | HL_A |
| Organism: | Homo sapiens, Plasmodium falciparum NF54 |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1038/s41467-017-01924-3 |
| Antibody | |
| Antibody: | 1269 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Pfs25 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6B0A_H|Chain A[auth H]|1269 antibody, heavy chain|Homo sapiens (9606) EVQLVESGGGLVQSGGSLRLSCAASGFTFSRNAMNWVRQAPGKGLEWVSTISGSGDSTYYADSVKGRFTISRDNSKNTLYLQVNSLRAEDTAVYYCAKGDYYFDSGSYSFGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >6B0A_L|Chain B[auth L]|1269 antibody, light chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRTSQSVSSSYLAWYQQKPGQAPRLLMYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGNSFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6B0A_A|Chain C[auth A]|25 kDa ookinete surface antigen|Plasmodium falciparum (5843) TGAKVTVDTVCKRGFLIQMSGHLECKCENDLVLVNEETCEEKVLKCDEKTVNKPCGDFSKCIKIDGNPVSYACKCNLGYDMVNNVCIPNECKQVTCGNGKCILDTSNPVKTGVCSCNIGKVPNVQDQNKCSKDGETKCSLKCLKEQETCKAVDGIYKCDCKDGFIIDQESSICTGTKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: PHE27 THR28 SER30 ARG31 ASN32 ALA33 THR50 SER52 GLY53 SER54 ASP56 SER57 TYR59 ASN74 GLY99 ASP100 TYR101 TYR102 PHE103 GLY106 TYR108 PHE110 ASP113 L: SER30 TYR33 TYR50 THR57 GLN91 TYR92 GLY93 A: SER18 GLY19 ASN87 GLU88 GLN91 VAL92 THR93 ILE100 ASP102 SER104 ASN105 PRO106 VAL107 LYS108 THR109 GLY110 VAL111 CYS112 VAL119 PRO120 VAL122 GLN123 GLN125 ASN126 LYS127 LYS130 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
