Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2042 |
| PDBID: | 6B08 |
| Chains: | CB_A |
| Organism: | Homo sapiens, Plasmodium falciparum |
| Method: | XRD |
| Resolution (Å): | 2.20 |
| Reference: | 10.1038/s41467-017-01924-3 |
| Antibody | |
| Antibody: | 1276 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Pfs25 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6B08_C|Chain A[auth C]|1276 antibody, heavy chain|Homo sapiens (9606) QVQLVQSGPEVKKPGASVKVSCKASGYTFTDYYIHWVRQAPGQGLEWMGWINPNSGGTNYAQNFQDWVTMTRDTSITTAYMELSSLRSDDTAVYYCARDRITTAAPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: B
Mutation: NULL
| >6B08_B|Chain B|1276 antibody, light chain|Homo sapiens (9606) SYVLTQPPSVSVAPGKTAKITCGGNNIGSKSVHWYQQKPGQAPVLVMYYDFDRPSGIPERFSGSNSGNTATLTISRVEAEDEADYYCQVWDSDRYWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6B08_A|Chain C[auth A]|Pfs25|Plasmodium falciparum (5833) TGAKVTVDTVCKRGFLIQMSGHLECKCENDLVLVNEETCEEKVLKCDEKTVNKPCGDFSKCIKIDGNPVSYACKCNLGYDMVNNVCIPNECKQVTCGNGKCILDTSNPVKTGVCSCNIGKVPNVQDQNKCSKDGETKCSLKCLKEQETCKAVDGIYKCDCKDGFIIDQESSICTGTKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: VAL2 THR30 ASP31 TYR32 TYR33 TRP50 ASN53 SER54 ARG94 ARG96 ILE97 THR98 THR99 ASP101 TYR102 B: GLY29 SER30 LYS31 SER32 LEU46 TYR49 TYR50 ASP51 PHE52 ASP53 PRO55 SER56 ASN66 TRP91 SER93 A: LEU75 GLY76 ASP78 ASN87 GLU88 LYS90 GLN91 VAL92 THR93 ASP102 ASN105 PRO106 VAL107 LYS108 THR109 GLY110 VAL111 CYS112 VAL122 GLN123 GLN125 ASN126 LYS127 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
