Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2030 |
| PDBID: | 6AQ7 |
| Chains: | HL_A |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.83 |
| Reference: | 10.1111/febs.14438 |
| Antibody | |
| Antibody: | POM6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Major prion protein |
| Antigen mutation: | No |
| Durg Target: | P04156 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6AQ7_H|Chain B[auth H]|POM6 FAB Heavy CHAIN|Mus musculus (10090) VKLQESGPQLVRPGSSVKISCKASGYSFTGYFMHWVRQTRVKSLEWIGRINPYNGNTNYNKIFKKKATLTVDKSSSTAYMQLNSLTSDDSAVYFCARSQDAWDYWGQGVTITVSSAKTTPPSVYPLAPSAAAANSMVTLGCLVKGYFPEPVTVTWNSGSLSGGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETITCNVAHPASSTKVDKKIVPR |
Light Chain: L
Mutation: NULL
| >6AQ7_L|Chain C[auth L]|POM6 FAB light CHAIN|Mus musculus (10090) DIVMTQSPAVLATSNGERATITCKASMSVSTSTYSYMDWYQQKPGQPPKLLIKKASNNETGVPARFSGSGTKKDFTLTIHPVQQEDVSTYYCQHSWQTPLTFGAGTVLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSETDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRA |
Antigen
Chain: A
Mutation: NULL
| >6AQ7_A|Chain A|Major prion protein|Mus musculus (10090) MGSSHHHHHHSSGLVPRGSHMGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR29 GLY30 TYR31 PHE32 HIS34 ARG49 ASN51 TYR53 ASN54 ASN56 LYS73 SER98 GLN99 ASP100 L: THR33 TYR34 TYR36 LYS54 ASN57 SER95 TRP96 GLN97 LEU100 A: TRP144 GLU145 ARG147 TYR148 GLU151 ASN152 ARG155 HIS176 VAL179 ASN180 LYS184 ASN196 PHE197 THR198 GLU199 THR200 VAL202 LYS203 MET204 GLU206 GLU210 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
