Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2027 |
| PDBID: | 6APD |
| Chains: | KM_B |
| Organism: | Respiratory syncytial virus, Human immunodeficiency virus 1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 4.10 |
| Reference: | 10.1016/j.immuni.2018.01.005 |
| Antibody | |
| Antibody: | ADI-19425 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Respiratory syncytial virus (RSV) Fusion glycoprotein F0 |
| Antigen mutation: | Yes |
| Durg Target: | P03420; P11209; P03420; P11209; |
Sequence information
Antibody
Heavy Chain: K
Mutation: NULL
| >6APD_K|Chain J, K, N|Immunoglobulin heavy variable 3-21,Immunoglobulin gamma-1 heavy chain|Homo sapiens (9606) EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLGYCSGGSCHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCD |
Light Chain: M
Mutation: NULL
| >6APD_M|Chain L, M, O|IGL@ protein|Homo sapiens (9606) QSVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGFYVFGTGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: B
Mutation: N67I/P102A
| >6APD_B|Chain A, B, C|Fusion glycoprotein F0,Envelope glycoprotein|Respiratory syncytial virus (12814) MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKEIKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGSMEVLFQGPGHHHHHHHHSAWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| K: THR28 SER30 SER31 TYR32 SER33 SER52 SER53 SER55 TYR56 TYR58 LEU95 TYR97 CYS98 SER99 M: GLY28 ALA29 GLY30 TYR31 LYS66 TYR91 SER93 TYR96 B: LEU45 THR50 GLY51 VAL178 SER186 ASN262 ASP263 MET264 PRO265 ILE266 THR267 ASN268 ASP269 GLN270 LYS271 LYS272 LEU273 LEU305 GLY307 VAL308 ILE309 ASP310 THR311 PRO312 ASP344 ASN345 ALA346 GLY347 ARG364 SER377 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
