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Entry information

Complex
AACDB_ID: 2023
PDBID: 6APD
Chains: DE_A
Organism: Respiratory syncytial virus, Human immunodeficiency virus 1, Homo sapiens
Method: XRD
Resolution (Å): 4.10
Reference: 10.1016/j.immuni.2018.01.005
Antibody
Antibody: AM22 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Respiratory syncytial virus (RSV) Fusion glycoprotein F0
Antigen mutation: Yes
Durg Target: P03420; P11209; P03420; P11209;

Sequence information

Antibody

Heavy Chain: D
Mutation: NULL

>6APD_D|Chain D, F, H|AM22 Fab Heavy Chain,IGH@ protein|Homo sapiens (9606)
QVQLVQSGAEVKKPGATVKVSCKISGHTLIKLSIHWVRQAPGKGLEWMGGYEGEVDEIFYAQKFQHRLTVIADTATDTVYMELGRLTSDDTAVYFCGTLGVTVTEAGLGIDDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCD

Light Chain: E
Mutation: NULL

>6APD_E|Chain E, G, I|AM22 Fab Light Chain,Uncharacterized protein|Homo sapiens (9606)
EIVLTQSPGTLSLSPGERATLSCRASQIVSRNHLAWYQQKPGQAPRLLIFGASSRATGIPVRFSGSGSGTDFTLTINGLAPEDFAVYYCLSSDSSIFTFGQGTKVDFKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Antigen

Chain: A
Mutation: N67I/P102A

>6APD_A|Chain A, B, C|Fusion glycoprotein F0,Envelope glycoprotein|Respiratory syncytial virus (12814)
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKEIKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGSMEVLFQGPGHHHHHHHHSAWSHPQFEK

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

D: HIS27 LYS31 LEU32 GLU53 THR98 ASP100 ASP101 TYR102

E: LEU46 PHE49 SER53 ARG54 ALA55 THR56 GLY57

A: LYS68 ASN70 GLY71 THR72 ASP73 TYR198 LYS201 GLN202 LEU203 PRO205 ILE206 ASN208 LYS209 GLN210 SER211 CYS212 SER213 ILE214 PRO215 ASN216 THR219

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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