Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 202 |
| PDBID: | 1ZA3 |
| Chains: | BA_S |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.35 |
| Reference: | 10.1016/j.jmb.2005.03.041 |
| Antibody | |
| Antibody: | YSd1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Tumor necrosis factor receptor superfamily member 10B (DR5) |
| Antigen mutation: | No |
| Durg Target: | O14763 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >1ZA3_B|Chain B, E[auth H]|Fab-YSd1 heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFSIYSYSIHWVRQAPGKGLEWVASISPYSGYTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRYSSYYSYYYSSSSYSYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH |
Light Chain: A
Mutation: NULL
| >1ZA3_A|Chain A, D[auth L]|Fab-YSd1 light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYAASYLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQSSSSPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: S
Mutation: NULL
| >1ZA3_S|Chain C[auth R], F[auth S]|Tumor necrosis factor receptor superfamily member 10B|Homo sapiens (9606) GSHMALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKES |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition A: ASP1 ILE2 GLN27 ASP28 VAL29 ASN30 THR31 ALA32 ALA50 SER92 SER93 PRO94 TYR95 B: TYR53 SER54 GLY55 TYR56 THR57 ASP61 SER62 LYS64 ARG66 ARG83 SER97 TYR98 TYR99 S: PRO23 GLU25 GLY26 LEU27 ILE34 SER35 GLU36 ASP37 GLY38 THR52 HIS53 TRP54 ASN55 ASP56 LEU57 LEU58 PHE59 LEU61 ARG62 GLU94 ASP95 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
