Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2019 |
| PDBID: | 6AJ9 |
| Chains: | HL_C |
| Organism: | Mus musculus, enterovirus D68 |
| Method: | EM |
| Resolution (Å): | 3.50 |
| Reference: | 10.1038/s41564-018-0275-7 |
| Antibody | |
| Antibody: | 15C5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Enterovirus D68 Capsid protein VP3 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6AJ9_H|Chain D[auth H]|VH of Fab 15C5|Mus musculus (10090) QVQLQQSGTELAKPGASVKMSCKASGYTFTNYWMHWFKQRPGQGLEWIGYVNPNTDYTDYNHKFKDKATLTADKSSSTAYMQLSSLTSEDSAVYFCARGTFGNYASFAYWGQGTLV |
Light Chain: L
Mutation: NULL
| >6AJ9_L|Chain C[auth L]|VL of Fab 15C5|Mus musculus (10090) DIQMIQSPSSMFASLGDRVSLSCRASQDIRGNLDWYQQKPGGTIKLLIYSTSNLNSGVPSRFSGSGSGSDYSLTISSLESEDFADYYCLQRNAYPLTFGGGTKLEIK |
Antigen
Chain: C
Mutation: NULL
| >6AJ9_C|Chain G[auth C]|Capsid protein VP3|Enterovirus D68 (42789) GVPTYLLPGSGQFLTTDDHSSAPALPCFNPTPEMHIPGQVRNMLEVVQVESMMEINNTESAVGMERLKVDISALTDVDQLLFNIPLDIQLDGPLRNTLVGNISRYYTHWSGSLEMTFMFCGSFMATGKLILCYTPPGGSCPTTRETAMLGTHIVWDFGLQSSVTLIIPWISGSHYRMFNNDAKSTNANVGYVTCFMQTNLIVPSESSDTCSLIGFIAAKDDFSLRLMRDSPDIGQLDHLHAAEAAYQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR49 SER50 ASN53 SER56 SER60 ARG91 H: TYR32 ARG98 THR100 PHE101 GLY102 TYR104 SER106 C: SER60 SER72 ALA73 LEU74 THR75 ASP76 VAL77 GLN79 THR198 ASN199 LEU200 VAL202 ASP208 THR209 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
