Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2018 |
| PDBID: | 6AJ9 |
| Chains: | DE_A |
| Organism: | Mus musculus, enterovirus D68 |
| Method: | EM |
| Resolution (Å): | 3.50 |
| Reference: | 10.1038/s41564-018-0275-7 |
| Antibody | |
| Antibody: | 11G1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Enterovirus D68 Capsid protein VP1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >6AJ9_D|Chain B[auth D]|VH of Fab 11G1|Mus musculus (10090) QVQLQQSGAELVRPGVSVKISCKGSGYIFTDYVMHWVKQSHSKSLEWIGVISTYYGDGSYNQKFKGKATMTVDKSSSTAYMELARLTSEDSAIYYCVRGENYYGVSGTMDYWGQGTSVTVSS |
Light Chain: E
Mutation: NULL
| >6AJ9_E|Chain A[auth E]|VL of Fab 11G1|Mus musculus (10090) DIVMSQSPSSLAVSVGEKVTMSCKSSQSLLYSNNQKNYLAWYQQKPGQSPQLLIYWASTRESGVPDRFTGSESGTDFTLTISSVKAEDLAVFYCQQYYNYPWTFGGGTKLEIK |
Antigen
Chain: A
Mutation: NULL
| >6AJ9_A|Chain E[auth A]|Capsid protein VP1|Enterovirus D68 (42789) IESIIKTATDTVKSEINAELGVVPSLNAVETGATSNTEPEEAIQTRTVINQHGVSETLVENFLSRAALVSKRSFEYKDHTSSAAQADKNFFKWTINTRSFVQLRRKLELFTYLRFDAEITILTTVAVNGSGNNTYVGLPDLTLQAMFVPTGALTPEKQDSFHWQSGSNASVFFKISDPPARITIPFMCINSAYSVFYDGFAGFEKNGLYGINPADTIGNLCVRIVNEHQPVGFTVTVRVYMKPKHIKAWAPRPPRTLPYMSIANANYKGKERAPNALNAIIGNRDSVKTMPHNIV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: SER28 LEU30 TYR31 SER32 ASN33 GLN35 TYR38 TYR97 TYR98 ASN99 TYR100 TRP102 D: VAL33 VAL50 SER52 TYR54 TYR55 GLY56 ASP57 GLY58 SER59 ASN101 TYR103 GLY104 VAL105 SER106 GLY107 A: HIS79 THR80 SER81 SER82 ALA83 ALA84 ALA86 ASP87 LYS157 GLN158 ASP159 SER160 PHE161 GLN164 GLU227 HIS228 GLN229 VAL231 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
