Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2000 |
| PDBID: | 6A67 |
| Chains: | HL_A |
| Organism: | Homo sapiens, Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) |
| Method: | XRD |
| Resolution (Å): | 2.33 |
| Reference: | 10.1074/jbc.RA118.004604 |
| Antibody | |
| Antibody: | FLD21.140 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H5N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6A67_H|Chain A[auth C], C[auth H]|FLD21.140 Heavy Chain|Homo sapiens (9606) QVQLQESGPGLVKPSQTLSLTCTVSGGSISSGTYYWSWIRHHPGKGLEWIGYIYHSGSAYYNPSLESRVTMSVDTSKNQFSLKLSSVTAADTAIYYCARAENLLSPYLAEGFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: L
Mutation: NULL
| >6A67_L|Chain B[auth D], D[auth L]|FLD21.140 Light Chain|Homo sapiens (9606) QSVLTQPPSASGTPGQRVTISCSGSTSNIGSNAVNWYQQLPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLSGSWVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6A67_A|Chain E[auth A], F[auth B]|Hemagglutinin|Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) (266827) DGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKANPVNDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSSHEASLGVSSACPYQRKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSTIMKSEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR33 TYR35 TYR54 HIS55 SER56 GLY57 SER58 ALA59 TYR60 GLU101 ASN102 LEU103 LEU104 SER105 PRO106 TYR107 L: SER31 TYR50 GLN54 TRP92 SER97 GLY98 A: GLU126 SER128 LEU129 VAL131 SER132 SER133 ARG139 LYS140 SER141 TRP149 ILE151 LYS152 LYS153 ASN154 SER155 ALA185 GLU186 LYS189 LEU190 LYS218 GLN222 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
