Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2 |
| PDBID: | 1A2Y |
| Chains: | BA_C |
| Organism: | Mus musculus, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 1.50 |
| Reference: | 10.1021/bi980148j |
| Antibody | |
| Antibody: | D1.3 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Lysozyme C |
| Antigen mutation: | Yes |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >1A2Y_B|Chain B|IGG1-KAPPA D1.3 FV (HEAVY CHAIN)|Mus musculus (10090) QVQLQESGPGLVAPSQSLSITCTVSGFSLTGYGVNWVRQPPGKGLEWLGMIWGDGNTDYNSALKSRLSISKDNSKSQVFLKMNSLHTDDTARYYCARERDYRLDYWGQGTTLTVSS |
Light Chain: A
Mutation: NULL
| >1A2Y_A|Chain A|IGG1-KAPPA D1.3 FV (LIGHT CHAIN)|Mus musculus (10090) DIVLTQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYYTTTLADGVPSRFSGSGSGTQYSLKINSLQPEDFGSYYCQHFWSTPRTFGGGTKLEIK |
Antigen
Chain: C
Mutation: D18A
| >1A2Y_C|Chain C|LYSOZYME|Gallus gallus (9031) KVFGRCELAAAMKRHGLANYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: HIS30 TYR32 TYR49 TYR50 THR52 THR53 PHE91 TRP92 SER93 B: THR30 GLY31 TYR32 TRP52 GLY53 ASP54 ARG99 ASP100 TYR101 ARG102 C: ALA18 ASN19 GLY22 TYR23 SER24 LEU25 ASN27 GLY102 ASN103 LYS116 GLY117 THR118 ASP119 VAL120 GLN121 ILE124 ARG125 GLY126 ARG128 LEU129 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
