Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1997 |
| PDBID: | 6A4K |
| Chains: | IM_B |
| Organism: | Influenza A virus (A/California/7/2009(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.15 |
| Reference: | 10.1038/s41598-019-40937-4 |
| Antibody | |
| Antibody: | 32D6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >6A4K_I|Chain B[auth H], E[auth I], H[auth J], K|immunoglobulin Fab heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSETLSLTCTVSGGSVNTGSYYWSWIRQPPGKGLEWIAYSSVSGTSNYNPSLKSRVTLTVDTSKNQFSLSVRSVTAADTAVYFCARLNYDILTGYYFFDFWGQGTLVIVSSASTKGPSVFPLAPSSKSASGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSSGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHHHH |
Light Chain: M
Mutation: NULL
| >6A4K_M|Chain C[auth L], F[auth M], I[auth N], L[auth O]|immunoglobulin Fab light chain|Homo sapiens (9606) QVELTQSPSASASLGTSVKLTCTLSSGHSTYAIAWHQQRPGKGPRYLMNLSSGGRHTRGDGIPDRFSGSSSGADRYLIISSLQSEDEADYYCQTWDAGMVFGGGTKLTVLGQSKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: B
Mutation: NULL
| >6A4K_B|Chain A, D[auth B], G[auth C], J[auth D]|Hemagglutinin|Influenza A virus (A/California/7/2009(H1N1)) (1316510) GVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETPSSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADAYVFVGSSRYSKKFKPEIAIRPKVRDQEGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| I: TYR35 TYR52 GLY57 THR58 TYR102 ILE104 LEU105 THR106 GLY107 TYR108 TYR109 M: GLN2 THR31 TYR32 ALA33 TRP96 ASP97 ALA98 B: LYS170 LYS171 GLY172 ASN173 SER174 TYR175 PRO176 LYS177 SER202 GLN206 GLN210 ASN211 ALA212 ASP213 TYR215 THR262 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
