Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1991 |
| PDBID: | 6A0Z |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/chicken/Chachoengsao/Thailand/CU-11/04(H5N1)), Human immunodeficiency virus 1, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.33 |
| Reference: | 10.1128/JVI.00547-18 |
| Antibody | |
| Antibody: | 13D4 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H5N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6A0Z_H|Chain B[auth H]|Antibody 13D4, Fab Heavy Chain|Mus musculus (10090) QVQLQQSGAELMKPGASVKISCKATGYTFSGHWIEWVKQRPGHGLEWIGEILPGSGNIHYNEKFKGKATFAADTSSNTAYMQLSSLTSEDSAVYYCARLGTTAVERDWYFDVWGAGTTVTVSLADPSAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRG |
Light Chain: L
Mutation: NULL
| >6A0Z_L|Chain C[auth L]|Antibody 13D4, Fab Light Chain|Mus musculus (10090) DIVMTQSQKFMSASVGDRVSVTCKASQNVGTHLAWYQQKPGQSPKALIYSASYRYSGVPDRFTGSGSGTDFTLTISNVQSGDLADYFCQQYNNFPLTFGAGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTRDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >6A0Z_A|Chain A|Hemagglutinin,Envelope glycoprotein|Influenza A virus (337599) MDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKANPVNDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSSHEASLGVSSACPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSTIMKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRERRRKKRGLFGAIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKCDNECMESVRNGTYDYPQYSEEARLKREEISSGRLVPRGSPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: SER30 GLY31 TRP33 GLU50 GLY53 SER54 GLY55 ASN56 ILE57 HIS58 THR98 ALA99 L: ASN28 THR31 HIS32 SER50 TYR53 ASN92 ASN93 PHE94 A: GLU131 LEU133 GLY134 VAL135 SER136 SER137 SER145 TRP153 ILE155 LYS156 LYS157 ASN158 SER159 ASN186 ASP187 ALA188 ALA189 GLU190 THR192 LYS193 LEU194 GLN196 THR219 LYS222 GLN226 SER227 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
