Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1990 |
| PDBID: | 5ZS0 |
| Chains: | BA_C |
| Organism: | Mus musculus, Suid alphaherpesvirus 1 |
| Method: | XRD |
| Resolution (Å): | 3.29 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 7B11 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | pseudorabies virus Envelope glycoprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >5ZS0_B|Chain B|7B11 heavy chain|Mus musculus (10090) EVQLVESGGGLVKPGGSLKLSCAASGFTFNDYAMSWVRQSPEKRLEWVATISGGGSYSYYPDSVKGRFTISRDNAKNTLYLQMSSLRSDDTAIYYCTRQEGDFPLFDYWGQGTILTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSVTCNVAHPASSTKVDKKIVPR |
Light Chain: A
Mutation: NULL
| >5ZS0_A|Chain A|7B11 light chain|Mus musculus (10090) DIVVTQSPKFMSTSAGDRVSITCKARQDVGSAVNWYQQKPGQSPKLLIYRASTRHTGVPDRFTGSGSGTDFTLTISSVQSEDVADYFCQQYGNYDLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR |
Antigen
Chain: C
Mutation: NULL
| >5ZS0_C|Chain C|Envelope glycoprotein B,Envelope glycoprotein B|Suid alphaherpesvirus 1 (10345) TRAASASPAPGTGATPDGFSAEESLEEIDGAVSPGPSDAPDGEYGDLDARTAVRAAATERDRFYVCPPPSGSTVVRLEPEQACPEYSGGSGNDMLSRIAAAWCELQNKDRTLWGEMSRLNPSAVATAALGQRVSARMLGDVMAISRCVEVRGGVYVQNSMRVPGERGTCYSRPLVTFEHNGTGVIEGQLGDDNELLISRDLIEPCTGNHRRYFKLGGGYVYYEDYSYVRMVEVPETISTRVTLNLTHHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASP28 VAL29 GLY30 SER31 ALA32 ARG50 TYR91 GLY92 ASN93 TYR94 B: ASN30 ASP31 ALA33 SER52 GLY53 GLY54 SER56 TYR57 TYR59 GLN99 GLY101 ASP102 C: ARG615 VAL616 GLY618 GLU619 ARG620 GLY621 THR622 ILE656 GLU657 PRO658 CYS659 THR660 GLY661 ASN662 ARG664 ASP678 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
