Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 199 |
| PDBID: | 1Z3G |
| Chains: | HL_A |
| Organism: | Mus musculus, Plasmodium vivax Sal-1 |
| Method: | XRD |
| Resolution (Å): | 3.30 |
| Reference: | 10.1038/nsmb1024 |
| Antibody | |
| Antibody: | 2A8 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | ookinete surface protein Pvs25 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1Z3G_H|Chain B[auth H], D[auth I]|2A8 Fab Heavy Chain|Mus musculus (10090) QVQLQQPGAELVKPGASVKLSCKASGYTFTSYWMHWVKQRPGQGLEWIGMIHPHSGSTNYNEKFKSKATLTVDKSSSTAYMQLSSLTSEDSAVYYCARGWDVAYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRD |
Light Chain: L
Mutation: NULL
| >1Z3G_L|Chain A[auth L], C[auth M]|2A8 Fab Light Chain|Mus musculus (10090) QIVLTQSPAIMSASPGEKVTMTCSASSSVSYMNWYQQKSGTSPKRWIYDTSKLASGVPAHFRGSGSGTSYSLTISGMEAEDAATYYCQQWSSNPPTFGSGTKLEINRADTAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >1Z3G_A|Chain E[auth A], F[auth B]|ookinete surface protein Pvs25|Plasmodium vivax SaI-1 (126793) EAEASAVTVDTICKNGQLVQMSNHFKCMCNEGLVHLSENTCEEKNECKKETLGKACGEFGQCIENPDPAQVNMYKCGCIEGYTLKEDTCVLDVCQYKNCGESGECIVEYLSEIQSAGCSCAIGKVPNPEDEKKCTKTGETACQLKCNTDNEVCKNVEGVYKCQCMEGFTFDKEKNVCLGPHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR31 ARG45 TRP90 H: THR28 THR30 SER31 TYR32 TRP33 MET50 HIS52 HIS54 SER55 SER57 THR58 ASN59 LYS74 GLY99 TRP100 ASP101 A: LYS44 LEU47 GLY48 GLN56 ILE58 GLU59 ASN60 PRO61 ASP62 PRO63 GLN65 VAL66 ASN67 MET68 TYR69 GLY72 CYS73 ILE74 GLU75 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
