Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1968 |
| PDBID: | 5Y11 |
| Chains: | AB_C |
| Organism: | Homo sapiens, Severe fever with thrombocytopenia syndrome virus |
| Method: | XRD |
| Resolution (Å): | 2.10 |
| Reference: | 10.1073/pnas.1705176114 |
| Antibody | |
| Antibody: | MAb4-5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Severe fever with thrombocytopenia syndrome virus (SFTSV) glycoprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >5Y11_A|Chain A|MAb 4-5 heavy chain|Homo sapiens (9606) SEVQLVQSGAEVKEPRESLKISCKGSGYSFTNYWIGWVRQMPGKGLEWMGIIFPGDSDTRYSPSFQGQVTISADKSINTAYLQWSSLKASDTAIYYCARLKRRGFSGEGYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: B
Mutation: NULL
| >5Y11_B|Chain B|MAb 4-5 light chain|Homo sapiens (9606) ELTLTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECSHHHHHH |
Antigen
Chain: C
Mutation: NULL
| >5Y11_C|Chain C|Membrane glycoprotein polyprotein|Severe fever with thrombocytopenia virus (1003835) DSGPIICAGPIHSNKSADIPHLLGYSEKICQIDRLIHVSSWLRNHSQFQGYVGQRGGRSQVSYYPAENSYSRWSGLLSPCDADWLGMLVVKKAKGSDMIVPGPSYKGKVFFERPTFDGYVGWGCGSGKSRTESGELCSSDSGTSSGLLPSDRVLWIGDVACQPMTPIPEETFLELKSFSQSEFPDICKIDGIVFNQCEGESLPQPFDVAWMDVGHSHKIIMREHKTKWVQESSSKDFVCYKEGTGPCSESEEKTCKTSGSCRGDMQFCKVAGCEHGEEASEAKCRCSLVHKPGEVVVSYGGMRVRPKCYGFSRMMATLEVN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: SER28 ASN31 TYR32 TRP33 PHE52 GLY54 ASP55 ASP57 ARG59 LYS100 ARG101 ARG102 GLY103 PHE104 C: SER251 SER252 SER253 PHE256 LYS275 THR276 SER277 GLY278 SER279 MET284 GLN285 PHE286 CYS287 LYS288 VAL289 ALA290 GLY291 CYS292 GLU293 HIS294 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
