Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1965 |
| PDBID: | 5XS7 |
| Chains: | HL_A |
| Organism: | Mus musculus, Coxsackievirus A6 |
| Method: | EM |
| Resolution (Å): | 3.80 |
| Reference: | 10.1038/s41467-017-00477-9 |
| Antibody | |
| Antibody: | 1D5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Coxsackievirus A6 (CVA6) virus Genome polyprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5XS7_H|Chain B[auth H]|Heavy chain of Fab 1D5|Mus musculus (10090) EVQLVESGGGLVKPGGSLKLSCAASGFAFSTYDMSWVRQTPEKRLELVAHISSGGGYIYYPDTVKGRFTISRDNAKNTLYLQMSSLKSEDTAMYYCTRQKGLYYGFDYWGQGTTLTVSS |
Light Chain: L
Mutation: NULL
| >5XS7_L|Chain A[auth L]|Light chain of Fab 1D5|Mus musculus (10090) DIVMTQSHKFMSTSVGDRVSITCKASQDVNTAVAWYQQRPGQSPKLLIYSASYRYTGVPDRFTGSGSGTDFTFTISSVQAEDLAVYYCQQHYTTPHTFGGGTKLEIKR |
Antigen
Chain: A
Mutation: NULL
| >5XS7_A|Chain C[auth A]|Genome polyprotein|Coxsackievirus A6 (86107) NDPIANAVESAVSALADTTISRVTAANTTASTHSLGTGRVPALQAAETGASSNASDENLVETRCVMNRNGVNEASVEHFYSRAGLVGVVEVKDSGTSLDGYTVWPIDVMGFVQQRRKLELSTYMRFDAEFTFVSNLSNSTTPGMLLQYMYVPPGAPKPDGRKSYQWQTATNPSVFAKLSDPPPQVSVPFMSPATAYQWFYDGYPTFGEHKQATNLQYGQCPNNMMGHFAIRTVSESTTGKNVHVRVYMRIKHVRAWVPRPLRSQAYMVKNYPTYSQTITNTATDRASITTTDYEGGVPASPQRTS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ASN36 THR37 ALA38 TYR55 SER56 TYR66 HIS107 TYR108 THR109 THR114 H: SER57 SER58 GLY59 GLY62 GLY63 TYR64 GLY109 LEU110 TYR112 TYR113 A: SER94 GLY95 THR96 SER97 LEU98 ASP99 ASP159 GLY160 ARG161 LYS162 SER163 TYR164 GLU235 SER236 THR237 GLY239 LYS240 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
