Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1957 |
| PDBID: | 5XHV |
| Chains: | PQ_A |
| Organism: | Influenza A virus (A/California/07/2009(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.35 |
| Reference: | 10.1038/s41598-017-14823-w |
| Antibody | |
| Antibody: | S40 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: P
Mutation: NULL
| >5XHV_P|Chain C[auth H], E[auth P]|S40 heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTIGDFGIHWVRQAPGKGLEWVAGIWPFGGYTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARFVNWDGDYMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKAEPKSCHHHHHH |
Light Chain: Q
Mutation: NULL
| >5XHV_Q|Chain D[auth L], F[auth Q]|S40 light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQDVGFYVAWYQQKPGKAPKLLISWSSYLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYNYPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >5XHV_A|Chain A, B[auth E]|Hemagglutinin|Influenza A virus (A/California/07/2009(H1N1)) (641809) DTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETPSSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADAYVFVGSSRYSKKFKPEIAIRPKVRDQEGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPKGAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNIPSI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| P: ASP31 PHE32 TRP52 PHE54 VAL100 ASN101 ASP103 ASP105 TYR106 ASP108 Q: ASP28 VAL29 GLY30 PHE31 TYR32 TRP50 TYR53 TYR91 TYR92 A: SER121 PRO124 ASN125 PRO159 LYS160 SER162 LYS163 SER164 ILE166 PHE200 GLY202 SER203 SER204 ARG205 TYR206 SER207 LYS208 LYS209 GLY237 ASP238 LYS239 THR241 GLU243 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
