Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1949 |
| PDBID: | 5X8M |
| Chains: | BC_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.66 |
| Reference: | 10.1038/s41598-017-06002-8 |
| Antibody | |
| Antibody: | durvalumab Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Durvalumab(Approved) |
| Antigen | |
| Antigen: | Programmed cell death 1 ligand 1 (PD-L1) |
| Antigen mutation: | Yes |
| Durg Target: | Q9NZQ7 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >5X8M_B|Chain B|durvalumab heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYWMSWVRQAPGKGLEWVANIKQDGSEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGGWFGELAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTHHHHHH |
Light Chain: C
Mutation: NULL
| >5X8M_C|Chain C|durvalumab light chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRASQRVSSSYLAWYQQKPGQAPRLLIYDASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSLPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: Q30E
| >5X8M_A|Chain A|Programmed cell death 1 ligand 1|Homo sapiens (9606) AFTVTVPKDLYVVEYGSNMTIECKFPVEKELDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: ARG31 TRP33 ASN50 LYS52 SER56 GLU57 TYR59 GLU99 TRP102 PHE103 GLY104 GLU105 C: ARG28 SER30 SER31 TYR33 TYR92 GLY93 SER94 LEU95 TRP97 A: THR20 VAL23 ASP26 TYR56 GLU58 GLU60 ASP61 VAL111 TYR112 ARG113 MET115 ALA121 ASP122 TYR123 LYS124 ARG125 THR127 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
