Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1935 |
| PDBID: | 5X0T |
| Chains: | CD_F |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 6H8 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | CD147 C2 domain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >5X0T_C|Chain A, B[auth C]|6H8 Fab fragment heavy chain|Mus musculus (10090) MNFGLSWVFIVFLLKGVQSEVKLEESGGGLVQPGGSMKLSCVASGFTFSNFWMNWVRQSPEKGLEWVAEIRLKSNNYATHYAESVKGRFTISRDDSKSSVYLQMNNLRTEDTGIYYCTSYDYEYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCTSKP |
Light Chain: D
Mutation: NULL
| >5X0T_D|Chain C[auth B], D|6H8 Fab fragment light chain|Mus musculus (10090) MDTHTQVFISILLWLYGADGNIVMTQSPKSMSMSVGERVTLSCKASENVGTYVSWYQQKPEQSPKLLIYGASNRYTGVPDRFTGSGSATDFTLTISSVQAEDLADYHCGQSYSYPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: F
Mutation: NULL
| >5X0T_F|Chain E, F|Basigin|Homo sapiens (9606) MAAGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLLEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: THR47 ASN50 PHE51 TRP52 LEU72 SER74 ASN75 TYR120 ASP121 GLU123 TYR124 D: THR51 TYR52 LEU66 TYR69 ASN73 ARG74 TYR75 THR76 TYR112 SER113 F: LEU33 LYS36 GLU49 VAL50 ARG54 VAL60 VAL61 LEU62 LYS63 GLU64 ASP65 ALA66 LEU67 PRO68 GLY69 LYS71 GLU73 PHE74 LYS75 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
