Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 193 |
| PDBID: | 1YQV |
| Chains: | HL_Y |
| Organism: | Mus musculus, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 1.70 |
| Reference: | 10.1107/S0907444905007870 |
| Antibody | |
| Antibody: | HyHEL-5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hen Egg White Lysozyme |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1YQV_H|Chain B[auth H]|HyHEL-5 Antibody Heavy Chain|Mus musculus (10090) EVQLQQSGAELMKPGASVKISCKASGYTFSDYWIEWVKQRPGHGLEWIGEILPGSGSTNYHERFKGKATFTADTSSSTAYMQLNSLTSEDSGVYYCLHGNYDFDGWGQGTTLTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKILD |
Light Chain: L
Mutation: NULL
| >1YQV_L|Chain A[auth L]|HyHEL-5 Antibody Light Chain|Mus musculus (10090) MDIVLTQSPAIMSASPGEKVTMTCSASSSVNYMYWYQQKSGTSPKRWIYDTSKLASGVPVRFSGSGSGTSYSLTISSMETEDAATYYCQQWGRNPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: Y
Mutation: NULL
| >1YQV_Y|Chain C[auth Y]|Hen Egg White Lysozyme|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ASN31 TYR32 TYR34 ASP50 TRP91 GLY92 ARG93 PRO95 H: SER30 ASP31 TYR32 TRP33 GLU35 TRP47 GLU50 SER54 GLY55 SER56 THR57 ASN58 GLY95 ASN96 TYR97 ASP98 Y: GLN41 THR43 ASN44 ARG45 ASN46 THR47 ASP48 GLY49 THR51 TYR53 ARG61 ASP66 GLY67 ARG68 THR69 PRO70 GLY71 SER72 SER81 LEU84 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
