Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1926 |
| PDBID: | 5WK3 |
| Chains: | SR_B |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1016/j.bbrep.2017.11.005 |
| Antibody | |
| Antibody: | M116 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | C-C motif chemokine 17 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: S
Mutation: NULL
| >5WK3_S|Chain B[auth Q], D[auth S], F[auth U], H[auth W]|M116 HEAVY CHAIN|Homo sapiens (9606) EVQLVQSGAEVKKPGESLKISCKGSGYSFTSYWIGWVRQMPGKGLEWMGIIDPSDSDTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARVGPADVWDSFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCHHHHHH |
Light Chain: R
Mutation: NULL
| >5WK3_R|Chain A[auth P], C[auth R], E[auth T], G[auth V]|M116 LIGHT CHAIN|Homo sapiens (9606) DIVMTQSPDSLAVSLGERATINCKSSQSVLLSPWNSNQLAWYQQKPGQPPKLLIYGASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYLIPSTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >5WK3_B|Chain I[auth A], J[auth B], K[auth C], L[auth D]|C-C motif chemokine 17|Homo sapiens (9606) ARGTNVTRECCLEYFKGAIPLRKLKTWYQTSEDCSRDAIVFVTVQGRAICSDPNNKRVKNAVKYLQSLERS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| R: GLN27 LEU31 PRO33 TRP34 TYR98 LEU99 S: TRP33 ASP52 ASP55 ASP57 ARG59 VAL99 GLY100 PRO101 ALA102 ASP103 VAL104 TRP105 B: LEU21 ARG22 LYS23 LEU24 VAL44 GLN45 ASN60 ALA61 LYS63 TYR64 SER67 LEU68 ARG70 SER71 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
