Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1922 |
| PDBID: | 5WHK |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1074/jbc.M117.807396 |
| Antibody | |
| Antibody: | DX-2507 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | IgG receptor FcRn large subunit p51 |
| Antigen mutation: | No |
| Durg Target: | P55899 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5WHK_H|Chain A[auth H]|DX-2507 Fab heavy chain|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFSEYAMGWVRQAPGKGLEWVSSIGSSGGQTKYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLAIGDSYWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: L
Mutation: NULL
| >5WHK_L|Chain B[auth L]|DX-2507 Fab light chain|Homo sapiens (9606) QSALTQPASVSGSPGQSITISCTGTGSDVGSYNLVSWYQQHPGKAPKLMIYGDSQRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCASYAGSGIYVFGTGTKVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >5WHK_A|Chain C[auth A]|IgG receptor FcRn large subunit p51|Homo sapiens (9606) MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLU31 TYR32 ALA33 SER50 ILE51 GLY52 SER53 SER54 GLN57 LYS59 LEU99 ALA100 ILE101 L: SER27 GLY30 SER31 TYR32 ASN33 LEU34 GLY52 ASP53 GLN55 LYS68 SER69 TYR93 SER96 GLY97 TYR99 A: ALA81 LEU82 GLY83 GLY84 LYS85 GLY86 PRO87 TYR88 LEU112 ASN113 GLU115 GLY129 ASP130 TRP131 PRO132 GLU133 LEU135 ALA136 GLN139 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
