Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 192 |
| PDBID: | 1YNT |
| Chains: | DC_G |
| Organism: | Mus musculus, Finegoldia magna ATCC 29328, Toxoplasma gondii |
| Method: | XRD |
| Resolution (Å): | 3.10 |
| Reference: | 10.1016/j.jmb.2005.09.028 |
| Antibody | |
| Antibody: | 4F11E12 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SAG1 surface antigen (P30) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >1YNT_D|Chain B, D|4F11E12 Fab variable heavy chain region|Mus musculus (10090) QVQLQQSGAELVRPGVSVKISCKGSGYTFTDYGMHWVKQSHAKSLEWIGIISTYSGDASYNQKFKGKATMTVDKSSSTAYMELARLTSEDSAIYYCARSSTWYYFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR |
Light Chain: C
Mutation: NULL
| >1YNT_C|Chain A, C|4F11E12 Fab variable light chain region|Mus musculus (10090) DIQVTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE |
Antigen
Chain: G
Mutation: NULL
| >1YNT_G|Chain F, G|Major surface antigen p30|Toxoplasma gondii (5811) PPLVANQVVTCPDKKSTAAVILTPTENHFTLKCPKTALTEPPTLAYSPNRQICPAGTTSSCTSKAVTLSSLIPEAEDSWWTGDSASLDTAGIKLTVPIEKFPVTTQTFVVGCIKGDDAQSCMVTVTVQARASSVVNNVARCSYGADSTLGPVKLSAEGPTTMTLVCGKDGVKVPQDNNQYCSGTTLTGCNEKSFKDILPKLTENPWQGNASSDKGATLTIKKEAFPAESKSVIIGCTGGSPEKHHCTVKLEFAG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: SER1030 TYR1032 TYR1050 ARG1053 GLY1091 ASN1092 THR1093 LEU1094 TYR1096 D: THR1530 ASP1531 TYR1532 GLY1533 ILE1550 SER1552 THR1553 TYR1554 SER1555 ASP1557 ALA1558 SER1559 TYR1560 GLN1562 SER1599 SER1600 THR1601 TRP1602 TYR1603 G: THR3037 ALA3038 LEU3039 GLU3041 PRO3042 PRO3043 THR3044 TYR3047 PRO3049 ASN3050 GLN3052 SER3061 CYS3062 THR3063 SER3064 LYS3065 ALA3066 VAL3067 THR3068 SER3085 ILE3114 LYS3115 GLY3116 ASP3117 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
