Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 19 |
| PDBID: | 1CIC |
| Chains: | BA_C |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1038/348254a0 |
| Antibody | |
| Antibody: | anti-idiotype E225 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | D1.3 Fab light chain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >1CIC_B|Chain B|PROTEIN (IG HEAVY CHAIN V REGIONS)|Mus musculus (10090) QVQLQQPGSELVRPGASVKLSCKASGYTFTNYWMHWVKQRPGQGLEWIGNIYPGSGDSNYDEKFKSKATLTVDTSSSTAYMQLSGLTSEDSAVYYCARGLAFYFDHWGQGTTLTVSSALTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPEPVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSETVTCSVAHPASSTTVDKKLEPS |
Light Chain: A
Mutation: NULL
| >1CIC_A|Chain A|PROTEIN (IG HEAVY CHAIN V REGIONS)|Mus musculus (10090) DIVMTQSHKFMSTSVGDRVSITCKASQDVRIAVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTDFTLTISNVQSEDLADYFCQHCGSYPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLDSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: C
Mutation: NULL
| >1CIC_C|Chain C|PROTEIN (IG HEAVY CHAIN V REGIONS)|Mus musculus (10090) DIQMTQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYYTTTLADGVPSRFSGSGSGTQYSLKINSLQPEDFGSYYCQHFWSTPRTFGGGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLDSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ALA32 TRP50 CYS91 GLY92 SER93 TYR94 B: ASN31 TRP33 TYR52 SER55 ASP57 SER58 ASN59 LEU100 ALA101 PHE102 C: ASN28 HIS30 ASN31 TYR32 TYR49 TYR50 THR52 THR53 GLY64 SER65 GLY66 SER67 GLY68 TRP92 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
