Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1890 |
| PDBID: | 5W6G |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/Solomon Islands/3/2006(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.79 |
| Reference: | 10.1073/pnas.1715471115 |
| Antibody | |
| Antibody: | 6649 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5W6G_H|Chain C[auth H]|6649 antibody heavy chain|Homo sapiens (9606) QVQLQESGPGLVKTSETLSLTCTVSGGSIKNKDFFWAWIRQPPGKALEWIGSVFYSGGAYYNWSLRNRVTMSADTSKNQFSLKMTSVTASDTSFYYCATSYVDNWHAGLHWFDSWGRGTLVTVSGASTKGPSVFPLAPSSKSTSGGTVALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: L
Mutation: NULL
| >5W6G_L|Chain D[auth L]|6649 antibody light chain|Homo sapiens (9606) QSVLTQPPSVSGAPGQRVSISCTGTHSNIGAGFDVHWYQQLPGTAPKLLIYANNNRPSGVPDRFSGSKSGSSASLAITGLQAEDEADYYCQSFDSILSGDLVFGGGTKLTVLGQPKGAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >5W6G_A|Chain A|Hemagglutinin HA1|Influenza A virus (A/Solomon Islands/3/2006(H1N1)) (464623) ADPGYLLEDTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLGNCSVAGWILGNPECELLISRESWSYIVEKPNPENGTCYPGHFADYEELREQLSSVSSFERFEIFPKESSWPNHTTTGVSASCSHNGESSFYKNLLWLTGKNGLYPNLSKSYANNKEKEVLVLWGVHHPPNIGDQRALYHTENAYVSVVSSHYSRKFTPEIAKRPKVRDREGRINYYWTLLEPGDTIIFEANGNLIAPRYAFALSRGFGSGIINSNAPMDECDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRNIPSIQSR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: LYS30 LYS32 PHE35 PHE54 TYR55 SER56 GLY58 ALA59 TYR60 TRP63 VAL102 ASP103 ASN104 TRP105 HIS106 ALA107 L: HIS26 SER27 ALA31 PHE33 SER95 ILE96 LEU97 SER98 GLY99 A: PHE118 GLU119 ILE120 PHE121 PRO122 GLU124 SER125 SER126 PRO128 ASN129 LYS157 ASN163 LEU164 SER165 LYS166 SER167 TYR168 ALA169 ASN170 ASN171 LYS172 GLU173 GLY240 THR242 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
