Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 189 |
| PDBID: | 1XIW |
| Chains: | DC_A |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1073/pnas.0407359101 |
| Antibody | |
| Antibody: | UCHT1 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | T cell surface glycoprotein CD3 epsilon dimer chain |
| Antigen mutation: | No |
| Durg Target: | P07766 |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >1XIW_D|Chain D, H|immunoglobulin heavy chain variable region|Mus musculus (10090) EVQLQQSGPELVKPGASMKISCKASGYSFTGYTMNWVKQSHGKNLEWMGLINPYKGVSTYNQKFKDKATLTVDKSSSTAYMELLSLTSEDSAVYYCARSGYYGDSDWYFDVWGQGTTLTVFS |
Light Chain: C
Mutation: NULL
| >1XIW_C|Chain C, G|immunoglobulin light chain variable region|Mus musculus (10090) MDIQMTQTTSSLSASLGDRVTISCRASQDIRNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSKFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPWTFAGGTKLEIK |
Antigen
Chain: A
Mutation: NULL
| >1XIW_A|Chain A, E|T-cell surface glycoprotein CD3 epsilon chain|Homo sapiens (9606) MDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: ARG31 TYR33 GLY92 ASN93 THR94 LEU95 TRP97 D: SER28 THR30 GLY31 THR33 LEU50 ASN52 TYR54 LYS55 VAL57 THR59 TYR101 TYR102 GLY103 ASP104 ASP106 TRP107 A: GLU35 LEU37 TRP38 GLN39 ASN44 ILE45 GLY46 GLY47 ASP48 GLU49 LYS52 GLY55 SER56 ASP57 TYR78 ARG80 GLY81 SER82 LYS83 PRO84 GLU85 ASP86 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
