Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1882 |
| PDBID: | 5W42 |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/swine/Minnesota/A01134337/2010(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.57 |
| Reference: | 10.1038/s41467-018-04704-9 |
| Antibody | |
| Antibody: | H3v-47 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5W42_H|Chain C[auth H]|Fab H3v-47 heavy chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVRVSCKASGDTFSSYSITWVRQAPGHGLQWMGGIFPIFGSTNYAQKFDDRLTITTDDSSRTVYMELTSLRLEDTAVYYCARGASKVEPAAPAYSDAFDMWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH |
Light Chain: L
Mutation: NULL
| >5W42_L|Chain D[auth L]|Fab H3v-47 light chain|Homo sapiens (9606) DIVMTQSPGTLSLSPGERATLSCRTSQGVSSSYLAWYQQKPGQAPRLLISGSSSRATGIPDRFSGSGSGRDFTLTISRLEPEDSAVYYCQQYATSPTFGQGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >5W42_A|Chain A|Hemagglutinin|Influenza A virus (A/swine/Minnesota/A01134337/2010(H3N2)) (1159784) QKLPGSDNSMATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGRICNSPHQILDGKNCTLIDALLGDPHCDDFQNKEWDLFVERSTAYSNCYPYYVPDYATLRSLVASSGNLEFTQESFNWTGVAQDGSSYACRRGSVNSFFSRLNWLYNLNYKYPEQNVTMPNNDKFDKLYIWGVHHPGTDKDQTNLYVQASGRVIVSTKRSQQTVIPNIGSRPWVRGVSSIISIYWTIVKPGDILLINSTGNLIAPRGYFKIQSGKSSIMRSDAHIDECNSECITPNGSIPNDKPFQNVNKITYGACPRYVKQNTLKLATGMRNVPEKQTR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: ILE53 PHE54 GLY55 SER56 THR57 ASN58 TYR59 GLN61 ASP64 ASP65 L: ASP1 ILE2 GLY27 SER29 SER31 TYR32 ARG69 TYR91 ALA92 THR93 SER94 A: GLN57 LEU59 LYS62 ASP77 ASP78 GLN80 ASN81 LYS82 GLU83 GLU119 PHE120 THR121 GLN122 GLU123 SER124 ASP133 GLY134 SER135 ARG141 GLY142 VAL144 ASN145 SER146 PHE147 PHE148 SER149 ASN171 ASP172 LYS173 PHE174 ARG255 TYR257 LYS259 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
