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Entry information

Complex
AACDB_ID: 1881
PDBID: 5W2B
Chains: HL_A
Organism: Homo sapiens, Reston ebolavirus - Reston (1989)
Method: XRD
Resolution (Å): 2.25
Reference: 10.1107/S2059798318007878
Antibody
Antibody: 5W2B Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Reston ebolavirus nucleoprotein
Antigen mutation: No
Durg Target:

Sequence information

Antibody

Heavy Chain: H
Mutation: NULL

>5W2B_H|Chain A[auth H]|Fab Heavy Chain|Homo sapiens (9606)
EISEVQLVESGGGLVQPGGSLRLSCAASGFNISYSSIHWVRQAPGKGLEWVASIYSYSGYTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARSYWYHVGSWHYTGMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT

Light Chain: L
Mutation: NULL

>5W2B_L|Chain B[auth L]|Fab Light Chain|Homo sapiens (9606)
SDIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQSSSSLITFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Antigen

Chain: A
Mutation: NULL

>5W2B_A|Chain C[auth A]|Nucleoprotein|Reston ebolavirus (386032)
GAMAQSKSMQKLEETYHHLLRTQGPFEAINYYHMMKDEPVIFSTDDGKEYTYPDSLEEAYPPWLTEKERLDKENRYIYINNQQFFWPVMSPRDKFLAILQHHQ

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

Chain residues position delta_SASA : residuesposition

H: PHE30 ASN31 TYR34 TYR55 TYR57 SER58 TYR60 ARG101 TYR103 TRP104 TYR105 HIS106 VAL107 GLY108 TRP110 HIS111

L: VAL30 SER93 SER94 SER95

A: GLU649 TYR652 HIS653 LEU656 ARG657 THR658 GLN659 GLY660 PRO661 ILE665 TYR668 VAL676 ILE677 PHE678 SER679 THR680 ASP681 ASP682 GLY683 ASN716 ARG728 PHE731 LEU732 LEU735 GLN736 GLN739

2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.

Interacting residues (Atom distance based)

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