Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1872 |
| PDBID: | 5W1K |
| Chains: | QM_R |
| Organism: | Homo sapiens, Mammarenavirus juninense |
| Method: | XRD |
| Resolution (Å): | 3.99 |
| Reference: | 10.1038/s41467-018-04271-z |
| Antibody | |
| Antibody: | CR1-10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Mammarenavirus juninense GP |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: Q
Mutation: NULL
| >5W1K_Q|Chain D, I, O, Q|CR1-10 Fab heavy chain|Homo sapiens (9606) VQLQESGPGLVKPSQTLSLTCSVSGGSIGGSSYYWSWIRHHPGKGLEWIGYINYRGITHYNAALKSRVSMSVETSQNHFSLQLTSVTAADTAVYYCARLTSDCSGGNCYQAFDYWGQGSLVSVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP |
Light Chain: M
Mutation: NULL
| >5W1K_M|Chain C, H, M, N|CR1-10 Fab light chain|Homo sapiens (9606) IVLTQSPGTLSLSPGETATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASGRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGRSGYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE |
Antigen
Chain: R
Mutation: NULL
| >5W1K_R|Chain E, J, P, R|Pre-glycoprotein polyprotein GP complex|Junin mammarenavirus (2169991) DLPLLCTLNKSHLYIKGGNASFKISFDDIAVLLPEYDVIIQHPADMSWCSKSDDQIWLSQWFMNAVGHDWYLDPPFLCRNRTKTEGFIFQVNTSKTGINENYAKKFKTGMHHLYREYPDSCLDGKLCLMKAQPTSWPLQCPL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| M: SER30 TYR33 TYR92 ARG94 SER95 TYR97 Q: GLY30 GLY31 SER32 SER33 TYR35 TYR52 ASN54 TYR55 ARG56 ILE58 THR59 HIS60 ALA63 LYS66 LEU100 SER102 ASP103 CYS104 SER105 GLY106 CYS109 TYR110 R: ASP87 LEU88 VAL124 ILE125 GLN127 HIS128 PRO129 ALA130 ASP131 SER133 TRP134 LYS137 ASP139 ASP140 ILE142 TRP143 GLN146 TRP147 ASN150 ASP155 TRP156 TYR157 ARG167 THR168 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
