Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1867 |
| PDBID: | 5W1K |
| Chains: | GF_E |
| Organism: | Homo sapiens, Mammarenavirus juninense |
| Method: | XRD |
| Resolution (Å): | 3.99 |
| Reference: | 10.1038/s41467-018-04271-z |
| Antibody | |
| Antibody: | CR1-28 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Mammarenavirus juninense GP |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >5W1K_G|Chain B, G, L, T|CR1-28 Fab heavy chain|Homo sapiens (9606) QVQLVESGGGVVQPGRSLRLSCAASGFTFSSSAMHWVRQAPGKGLEWVAVIWSDGSNENYADSVKGRFTISRDNSKNTLYLQMSSLRAEDTAVYYCATDKTYVSGYTSTWYYFNYWGQGTLVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP |
Light Chain: F
Mutation: NULL
| >5W1K_F|Chain A, F, K, S|CR1-28 Fab light chain|Homo sapiens (9606) IQMTQSPSTLSASVGDRVTITCRASQSIDNWLAWYQQKPGKAPKLLIYTASRLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQHRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG |
Antigen
Chain: E
Mutation: NULL
| >5W1K_E|Chain E, J, P, R|Pre-glycoprotein polyprotein GP complex|Junin mammarenavirus (2169991) DLPLLCTLNKSHLYIKGGNASFKISFDDIAVLLPEYDVIIQHPADMSWCSKSDDQIWLSQWFMNAVGHDWYLDPPFLCRNRTKTEGFIFQVNTSKTGINENYAKKFKTGMHHLYREYPDSCLDGKLCLMKAQPTSWPLQCPL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| F: ILE2 GLN27 SER28 ILE29 ASP30 ASN31 TRP32 THR50 ARG53 SER67 HIS90 ARG91 G: TRP52 ASP54 GLY55 SER56 GLU58 TYR102 SER104 GLY105 TYR106 THR107 SER108 THR109 TRP110 E: SER111 ASP113 ASP114 ILE115 ALA116 VAL117 LEU118 LEU119 PRO120 GLU121 TYR122 ARG165 THR168 LYS169 THR170 GLU171 ILE174 ASN178 LEU212 LEU214 LYS216 GLN218 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
