Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1863 |
| PDBID: | 5W0D |
| Chains: | BC_A |
| Organism: | Influenza A virus (A/Solomon Islands/3/2006(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1016/j.immuni.2017.12.009 |
| Antibody | |
| Antibody: | Lineage K03.12 UCA Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >5W0D_B|Chain B|Lineage K03.12 UCA antibody heavy chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARDLTLMYVHSSGWERGVYYYYGMDVWGQGTTVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: C
Mutation: NULL
| >5W0D_C|Chain C|Lineage K03.12 UCA antibody light chain|Homo sapiens (9606) QSALTQPASVSGSPGQSITISCTGTSSDVGSYNLVSWYQQHPGKAPKLMIYEGSKRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCCSYAGSVVFGGGTKLTVLGQPKGAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >5W0D_A|Chain A|Hemagglutinin HA1|Influenza A virus (A/Solomon Islands/3/2006(H1N1)) (464623) ASAPLQLGNCSVAGWILGNPECELLISRESWSYIVEKPNPENGTCYPGHFADYEELREQLSSVSSFERFEIFPKESSWPNHTTTGVSASCSHNGESSFYKNLLWLTGKNGLYPNLSKSYANNKEKEVLVLWGVHHPPNIGDQRALYHTENAYVSVVSSHYSRKFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPRYAFALSRGFGSGLEVLF |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: LEU102 VAL105 HIS106 SER107 SER108 GLY109 TRP110 GLU111 ARG112 GLY113 VAL114 C: TYR51 GLU52 LYS55 A: TYR95 THR131 THR133 GLY134 VAL135 SER136 ALA137 GLU144 SER145 TRP153 THR155 ASN158 HIS183 PRO186 ASN187 ASP190 ALA193 LEU194 ASP225 GLN226 GLU227 GLY228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
