Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1854 |
| PDBID: | 5VYF |
| Chains: | HL_F |
| Organism: | Mus musculus, Felis catus |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1038/s41467-018-03636-8 |
| Antibody | |
| Antibody: | 5VYF Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Mevonlerbart(Phase-II) |
| Antigen | |
| Antigen: | Chimera of Major allergen I |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5VYF_H|Chain B, E[auth H]|Antibody Fab heavy chain|Mus musculus (10090) EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGRGYNADYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLEYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPP |
Light Chain: L
Mutation: NULL
| >5VYF_L|Chain A, D[auth L]|Antibody light chain|Mus musculus (10090) DIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKLLIYKASSLESGVPSRFSGSGSGTDFTLTISSLRPEDFATYYCQQYNSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: F
Mutation: NULL
| >5VYF_F|Chain C, F|Chimera of Major allergen I polypeptide chain 2,Major allergen I polypeptide chain 1|Felis catus (9685) VKMAETCPIFYDVFFAVANGNELLLDLSLTKVAATEPERTAMKKIQDCYVENGLISRVLDGLVMTTISSSKDCMGEAVQNTVEDLKLNTLGREICPAVKRDVDLFLTGTPDEYVEQVAQYKALPVVLENARILKNCVDAKMTEEDKENALSLLDKIYTSPLCGPGGEQKLISEEDLGGEQKLISEEDLSGHHHHHHSSG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TRP32 LYS50 TYR91 ASN92 SER93 TYR94 LEU96 H: PHE27 THR28 SER30 SER31 TYR32 ALA33 ALA50 ILE51 SER52 GLY53 ARG54 TYR56 ASN57 ALA58 ASP59 LEU99 GLU100 TYR101 F: ILE9 GLY20 ASN21 GLU22 LEU23 LEU24 ASP26 LEU27 THR30 LYS31 ALA34 GLU36 ARG39 THR40 LYS43 LYS44 GLN46 ASP47 LEU161 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
