Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1842 |
| PDBID: | 5VPH |
| Chains: | DC_A |
| Organism: | Dermatophagoides pteronyssinus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1074/jbc.M111.311159 |
| Antibody | |
| Antibody: | 4C1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Der p 1 allergen |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >5VPH_D|Chain C[auth D]|FAB 4C1 - HEAVY CHAIN|Mus musculus (10090) EVQLQESGPGLVKPSQSLSLTCTVTGYSITSDYAWNWIRQFPGNKLEWMGYISYSGTTSYNPSLKSRISITRDTSKNQFFLQLNSVTTEDTATYYCGRTGVYRYPERAPYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTP |
Light Chain: C
Mutation: NULL
| >5VPH_C|Chain B[auth C]|FAB 4C1 - LIGHT CHAIN|Mus musculus (10090) QIVMTQSPFSMYATLGERVTITCKASQDIYSYLSWLQQKPGKSLKTLIYRANRLITGVPSRFSGSGSGQDYSLTISSLEYEDMGIYYCLQYDEFPYTFGGGTKLEMKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE |
Antigen
Chain: A
Mutation: NULL
| >5VPH_A|Chain A|Der p 1 allergen|Dermatophagoides pteronyssinus (6956) TNACSINGNAPAEIDLRQMRTVTPIRMQGGCGSCWAFSGVAATESAYLAYRNQSLDLAEQELVDCASQHGCHGDTIPRGIEYIQHNGVVQESYYRYVAREQSCRRPNAQRFGISNYCQIYPPNANKIREALAQTHSAIAVIIGIKDLDAFRHYDGRTIIQRDNGYQPNYHAVNIVGYSNAQGVDYWIVRNSWDTNWGDNGYGYFAANIDLMMIEEYPYVVIL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: TYR30 TYR32 ARG50 ARG53 ASP92 GLU93 D: THR30 SER31 ASP32 TYR54 SER55 ARG72 VAL101 TYR102 ARG103 TYR104 PRO105 GLU106 ARG107 A: GLU13 ASP15 ARG17 GLN18 ARG20 ASP154 GLY155 ARG156 THR157 ILE158 SER178 ALA180 GLN181 TYR185 ILE187 ASP198 ASN199 TYR201 TYR203 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
