Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1810 |
| PDBID: | 5VIG |
| Chains: | AB_G |
| Organism: | Homo sapiens, Zika virus |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1016/j.cell.2017.04.024 |
| Antibody | |
| Antibody: | Z006 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Zika virus envelope protein DIII |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >5VIG_A|Chain A, D[auth H]|Fab heavy chain|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFKNYAMAWVRQAPGKGLEWVSLLYNSEESTYYADSVKGRFTISRDNSKNTLFLQMNRLRVEDTAVYFCVRDRSNGWSSINLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Light Chain: B
Mutation: NULL
| >5VIG_B|Chain B, E[auth L]|Fab light chain|Homo sapiens (9606) DIQMTQSPSTLSASVGDRVTMTCRASQTISGWLAWYQQKPGKAPKLLIYQASRLESGIPSRFSGSGSGTEFTLTISSLQPDDVATYYCQQYSTFWTFGLGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: G
Mutation: NULL
| >5VIG_G|Chain C[auth G], F[auth Z]|Zika virus envelope protein DIII|Zika virus (64320) MRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGSTI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: THR28 LYS30 ASN31 TYR32 ASN52 GLU55 SER56 THR57 TYR58 ARG96 SER97 ASN98 GLY99 B: ILE2 GLN27 THR28 SER30 TRP32 GLN50 TYR91 SER92 THR93 PHE94 G: TYR305 SER306 LEU307 THR309 ALA310 ALA311 ALA333 GLY334 THR335 ASP336 LYS340 GLN350 THR351 LEU352 THR353 GLU370 VAL391 GLY392 GLU393 LYS394 LYS395 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
