Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1800 |
| PDBID: | 5VAG |
| Chains: | CB_A |
| Organism: | Influenza A virus (A/Shanghai/02/2013(H7N9)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1016/j.chom.2017.08.011 |
| Antibody | |
| Antibody: | m826 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H7N9 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >5VAG_C|Chain C|Heavy chain of antibody m826|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARDPSFWAAEYFQHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTSGQAGHHHHHHGDYKDDDDK |
Light Chain: B
Mutation: NULL
| >5VAG_B|Chain B|Light chain of antibody m826|Homo sapiens (9606) GDIQLTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >5VAG_A|Chain A|Hemagglutinin|Influenza A virus (1332244) DKICLGHHAVSNGTKVNTLTERGVEVVNATETVERTNIPRICSKGKRTVDLGQCGLLGTITGPPQCDQFLEFSADLIIERREGSDVCYPGKFVNEEALRQILRESGGIDKEAMGFTYSGIRTNGATSACRRSGSSFYAEMKWLLSNTDNAAFPQMTKSYKNTRKSPALIVWGIHHSVSTAEQTKLYGSGNKLVTVGSSNYQQSFVPSPGARPQVNGLSGRIDFHWLMLNPNDTVTFSFNGAFIAPDRASFLRGKSMGIQSGVQVDANCEGDCYHSGGTIISNLPFQNIDSRAVGKCPRYVKQRSLLLATGMKNVPEIPKGRG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: SER28 SER30 SER31 TYR32 TYR49 ALA50 SER52 SER53 SER56 SER67 SER91 TYR92 SER93 THR94 ARG96 C: SER30 SER31 ILE52 ILE54 PHE55 GLY56 THR57 ALA58 ASN59 TYR60 SER101 PHE102 TRP103 ALA104 ALA105 TYR107 GLN109 A: LYS109 VAL111 ASN112 GLU114 ALA115 GLN118 ILE119 GLU122 LYS182 SER183 PRO184 TRP189 HIS193 ASN217 TYR218 GLN219 GLN220 SER221 PHE222 VAL223 ASP240 HIS242 TRP243 LEU244 MET245 ASN247 PRO248 LEU269 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
